综合资源展示一 综合资源展示一

最小化 最大化
英语(164)
NPG(93)
Science(71)
美国(164)
科研(164)
 
 
 
 
 
     

1 Author Correction: The physics of spreading processes in multilayer networks 2018-02-24             

HTML   |   详细信息   |  

Author Correction: The physics of spreading processes in multilayer networks

Author Correction: The physics of spreading processes in multilayer networks, Published online: 23 February 2018; doi:10.1038/s41567-018-0065-4

Author Correction: The physics of spreading processes in multilayer networks

2 Ancient genomes revisit the ancestry of domestic and Przewalskis horses 2018-02-24             

HTML   |   详细信息   |  

The Eneolithic Botai culture of the Central Asian steppes provides the earliest archaeological evidence for horse husbandry, ~5,500 ya, but the exact nature of early horse domestication remains controversial. We generated 42 ancient horse genomes, including 20 from Botai. Compared to 46 published ancient and modern horse genomes, our data indicate that Przewalski’s horses are the feral descendants of horses herded at Botai and not truly wild horses. All domestic horses dated from ~4,000 ya to present only show ~2.7% of Botai-related ancestry. This indicates that a massive genomic turnover underpins the expansion of the horse stock that gave rise to modern domesticates, which coincides with large-scale human population expansions during the Early Bronze Age.

3 Early emergence of cortical interneuron diversity in the mouse embryo 2018-02-24             

HTML   |   详细信息   |  

GABAergic interneurons regulate neural circuit activity in the mammalian cerebral cortex. These cortical interneurons are structurally and functionally diverse. Here, we use single-cell transcriptomics to study the origins of this diversity in mouse. We identify distinct types of progenitor cells and newborn neurons in the ganglionic eminences, the embryonic proliferative regions that give rise to cortical interneurons. These embryonic precursors show temporally and spatially restricted transcriptional patterns that lead to different classes of interneurons in the adult cerebral cortex. Our findings suggest that shortly after the interneurons become postmitotic, their diversity is already patent in their diverse transcriptional programs, which subsequently guide further differentiation in the developing cortex.

4 Real-time imaging of DNA loop extrusion by condensin 2018-02-24             

HTML   |   详细信息   |  

It has been hypothesized that Structural Maintenance of Chromosomes (SMC) protein complexes such as condensin and cohesin spatially organize chromosomes by extruding DNA into large loops. Here, we provide unambiguous evidence for loop extrusion by directly visualizing the formation and processive extension of DNA loops by yeast condensin in real-time. We find that a single condensin complex is able to extrude tens of kilobase pairs of DNA at a force-dependent speed of up to 1,500 base pairs per second, using the energy of ATP hydrolysis. Condensin-induced loop extrusion is strictly asymmetric, which demonstrates that condensin anchors onto DNA and reels it in from only one side. Active DNA loop extrusion by SMC complexes may provide the universal unifying principle for genome organization.

5 Recurrences in an isolated quantum many-body system 2018-02-24             

HTML   |   详细信息   |  

The complexity of interacting quantum many-body systems leads to exceedingly long recurrence times of the initial quantum state for all but the smallest systems. For large systems, one cannot probe the full quantum state in all its details. Thus, experimentally, recurrences can only be determined on the level of the accessible observables. Realizing a commensurate spectrum of collective excitations in one-dimensional superfluids, we demonstrate recurrences of coherence and long range order in an interacting quantum many-body system containing thousands of particles. Our findings will enable the study of the dynamics of large quantum systems even after they have reached a transient thermal-like state.

6 Human brain organoids on a chip reveal the physics of folding 2018-02-20             

HTML   |   详细信息   |  

Human brain organoids on a chip reveal the physics of folding

Human brain organoids on a chip reveal the physics of folding, Published online: 19 February 2018; doi:10.1038/s41567-018-0046-7

Wrinkling in human brain organoids suggests that brain development may be mechanically driven, a notion supported only by model gels so far. Evidence in this simple living system highlights roles for cytoskeletal contraction and nuclear expansion.

7 Rethinking pattern formation in reaction–diffusion systems 2018-02-20             

HTML   |   详细信息   |  

Rethinking pattern formation in reaction–diffusion systems

Rethinking pattern formation in reaction–diffusion systems, Published online: 19 February 2018; doi:10.1038/s41567-017-0040-5

Canonical pattern formation relies on a system being close to an instability and stabilized by nonlinearities — but real systems seldom conform to these conditions. A new theory solves the problem by recasting it in terms of moving local equilibria.

8 A new wrinkle on the brain 2018-02-20             

HTML   |   详细信息   |  

A new wrinkle on the brain

A new wrinkle on the brain, Published online: 19 February 2018; doi:10.1038/s41567-018-0057-4

The folded structure of the human brain is a hallmark of our intelligence — an optimized packing of neurons into a confined space. Similar wrinkling in brain-on-a-chip experiments provides a way of understanding the physics of how this occurs.

9 Experimental discovery of nodal chains 2018-02-20             

HTML   |   详细信息   |  

Experimental discovery of nodal chains

Experimental discovery of nodal chains, Published online: 19 February 2018; doi:10.1038/s41567-017-0041-4

Nodal chains are observed for the first time in a photonic crystal with accompanying drumhead surface states. This will stimulate further study of topological nodal lines with non-trivial connectivity.

10 Photoexcitation circular dichroism in chiral molecules 2018-02-20             

HTML   |   详细信息   |  

Photoexcitation circular dichroism in chiral molecules

Photoexcitation circular dichroism in chiral molecules, Published online: 19 February 2018; doi:10.1038/s41567-017-0038-z

Photoexcitation circular dichroism generates an ultrafast response in chiral molecules, with a much higher sensitivity than standard circular dichroism.

 
共计:164条记录 页次:1/17    下一页 末页   跳转到第 页  

RSS采集 RSS采集

最小化 最大化
您还没有登录。 请先登录再使用本系统。