综合资源展示一 综合资源展示一

最小化 最大化
«返回

Rev-erb{alpha} dynamically modulates chromatin looping to control circadian gene transcription

  • 详细信息
标题: Rev-erb{alpha} dynamically modulates chromatin looping to control circadian gene transcription
资源摘要:

Mammalian physiology exhibits 24-hour cyclicity due to circadian rhythms of gene expression controlled by transcription factors (TF) that comprise molecular clocks. Core clock TFs bind to the genome at enhancer sequences to regulate circadian gene expression, but not all binding sites are equally functional. Here we demonstrate that circadian gene expression in mouse liver is controlled by rhythmic chromatin interactions between enhancers and promoters. Rev-erbα, a core repressive TF of the clock, opposes functional loop formation between Rev-erbα-regulated enhancers and circadian target gene promoters by recruitment of the NCoR-HDAC3 corepressor complex, histone deacetylation, and eviction of the elongation factor BRD4 and the looping factor MED1. Thus, a repressive arm of the molecular clock operates by rhythmically modulating chromatin loops to control circadian gene transcription.

资源原始URL http://science.sciencemag.org/cgi/content/short/science.aao6891v1?rss=1
资源来源机构: Science
来源机构所属国家: 美国
来源机构性质: 科研

RSS采集 RSS采集

最小化 最大化
您还没有登录。 请先登录再使用本系统。