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Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

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标题: Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
资源摘要:

Diurnal gene expression patterns underlie time of the day-specific functional specialization of tissues. However, available circadian gene expression atlases of a few organs are largely from nocturnal vertebrates. We report the diurnal transcriptome of 64 tissues, including 22 brain regions, sampled every 2 hours over 24 hours, from the primate Papio anubis (baboon). Genomic transcription was highly rhythmic with up to 81.7% of protein-coding genes showing daily rhythms in expression. In addition to tissue-specific gene expression, the rhythmic transcriptome imparts another layer of functional specialization. Most of ubiquitously expressed genes that participate in essential cellular functions exhibit rhythmic expression in a tissue-specific manner. The peak phases of rhythmic gene expression clustered around dawn and dusk with a "quiescent period" during early night. Our findings also unveil a different temporal organization of central and peripheral tissues between diurnal and nocturnal animals.

资源原始URL http://science.sciencemag.org/cgi/content/short/science.aao0318v1?rss=1
资源来源机构: Science
来源机构所属国家: 美国
来源机构性质: 科研

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