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1 Thirst regulates motivated behavior through modulation of brainwide neural population dynamics 2019-04-05             

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Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior. We studied dynamics from ~24,000 neurons in 34 brain regions during thirst-motivated choice behavior, as mice consumed water and became sated. Water-predicting sensory cues elicited activity that rapidly spread throughout the brain of thirsty animals. These dynamics were gated by a brainwide mode of population activity that encoded motivational state. Focal optogenetic activation of hypothalamic thirst-sensing neurons, after satiation, returned global activity to the pre-satiation state. Thus, motivational states specify initial conditions determining how a brainwide dynamical system transforms sensory input into behavioral output.

2 Close Cassini flybys of Saturns ring moons Pan, Daphnis, Atlas, Pandora, and Epimetheus 2019-03-30             

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Saturn’s main ring system is associated with a set of small moons that are either embedded within it, or interact with the rings to alter their shape and composition. Five close flybys of the moons Pan, Daphnis, Atlas, Pandora, and Epimetheus were performed between December 2016 and April 2017 during the Ring-grazing Orbits of the Cassini mission. Data on the moons’ morphology, structure, particle environment, and composition were returned, along with images in the ultraviolet and thermal infrared. The optical properties of the moons’ surfaces are determined by two competing processes: contamination by a red material formed in Saturn’s main ring system, and by accretion of bright icy particles or water vapor from volcanic plumes originating on the planet’s moon Enceladus.

3 Cell competition during reprogramming gives rise to dominant clones 2019-03-23             

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The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have identifed molecular networks that reprogram cells to pluripotency, the cellular dynamics of these processes remain poorly understood. Here, by combining cellular barcoding, mathematical modelling, and lineage tracing approaches, we demonstrate that reprogramming dynamics in heterogeneous populations are driven by dominant "elite" clones. Clones arise a priori from a population of poised mouse embryonic fibroblasts (MEFs) derived from Wnt1-expressing cells that may represent a neural crest population. This work highlights the importance of cellular dynamics in fate programming outcomes and uncovers cell competition as a mechanism by which cells with context-specific eliteness emerge to occupy and dominate the reprogramming niche.

4 Dont abandon evidence and process on air pollution policy 2019-03-23             

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Who decides how to establish causality?

5 The surface composition of asteroid 162173 Ryugu from Hayabusa2 near-infrared spectroscopy 2019-03-20             

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The near-Earth asteroid 162173 Ryugu, the target of Hayabusa2 sample return mission, is thought to be a primitive carbonaceous object. We report reflectance spectra of Ryugu’s surface acquired with the Near Infrared Spectrometer (NIRS3) on Hayabusa2, to provide direct measurements of the surface composition and geological context for the returned samples. A weak, narrow absorption feature centered at 2.72 μm was detected across the entire observed surface, indicating that hydroxyl (OH)-bearing minerals are ubiquitous there. The intensity of the OH feature and low albedo are similar to thermally- and/or shock-metamorphosed carbonaceous chondrite meteorites. There are few variations in the OH-band position, consistent with Ryugu being a compositionally homogeneous rubble-pile object, generated from impact fragments of an undifferentiated aqueously altered parent body.

6 The geomorphology, color, and thermal properties of Ryugu: Implications for parent-body processes 2019-03-20             

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The near-Earth carbonaceous asteroid 162173 Ryugu is thought to have been produced from a parent body that contained water ice and organic molecules. The Hayabusa2 spacecraft has obtained global multi-color images of Ryugu. Geomorphological features present include a circum-equatorial ridge, east/west dichotomy, high boulder abundances across the entire surface, and impact craters. Age estimates from the craters indicate a resurfacing age of years for the top 1-meter layer. Ryugu is among the darkest known bodies in the Solar System. The high abundance and spectral properties of boulders are consistent with moderately dehydrated materials, analogous to thermally metamorphosed meteorites found on Earth. The general uniformity in color across Ryugu’s surface supports partial dehydration due to internal heating of the asteroid’s parent body.

7 Hayabusa2 arrives at the carbonaceous asteroid 162173 Ryugu--A spinning top-shaped rubble pile 2019-03-20             

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The Hayabusa2 spacecraft arrived at the near-Earth carbonaceous asteroid 162173 Ryugu in 2018. We present Hayabusa2 observations of Ryugu’s shape, mass, and geomorphology. Ryugu has an oblate ‘spinning top’ shape with a prominent circular equatorial ridge. Its bulk density, 1.19 ± 0.02 g cm–3, indicates a high porosity (>50%) interior. Large surface boulders suggest a rubble-pile structure. Surface slope analysis shows Ryugu’s shape may have been produced if it once spun at twice the current rate. Coupled with the observed global material homogeneity, this suggests that Ryugu was reshaped by centrifugally induced deformation during a period of rapid rotation. From these remote-sensing investigations, we identify a suitable sample collection site on the equatorial ridge.

8 Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP {gamma}8 2019-03-16             

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AMPA-type glutamate receptors (AMPARs) mediate excitatory neurotransmission, and are central regulators of synaptic plasticity, a molecular mechanism underlying learning and memory. Although AMPARs act predominantly as heteromers, structural studies have focused on homomeric assemblies. Here we present a cryo-EM structure of the heteromeric GluA1/2 receptor associated with two TARP 8 auxiliary subunits, the principle AMPAR complex at hippocampal synapses. Within the receptor, the core subunits arrange to give the GluA2 subunit dominant control of gating. This structure reveals the geometry of the Q/R-site controlling calcium flux, suggests association of TARP-stabilized lipids, and demonstrates that the extracellular loop of 8 modulates gating by selectively interacting with the GluA2 ligand-binding domain. Collectively, this structure provides a blueprint for deciphering the signal transduction mechanisms of synaptic AMPARs.

9 Arc-continent collisions in the tropics set Earths climate state 2019-03-16             

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On multi-million-year timescales, Earth has experienced warm ice-free and cold glacial climates, but it is unknown if transitions between these background climate states were the result of changes in CO2 sources or sinks. Low-latitude arc-continent collisions are hypothesized to drive cooling by uplifting and eroding mafic and ultramafic rocks in the warm, wet tropics, thereby increasing Earth’s potential to sequester carbon through chemical weathering. To better constrain global weatherability through time, the paleogeographic position of all major Phanerozoic arc-continent collisions was reconstructed and compared to the latitudinal distribution of ice-sheets. This analysis reveals a strong correlation between the extent of glaciation and arc-continent collisions in the tropics. Earth’s climate state is set primarily by global weatherability, which changes with the latitudinal distribution of arc-continent collisions.

10 Ultrapotent chemogenetics for research and potential clinical applications 2019-03-16             

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Chemogenetics enables non-invasive chemical control over cell populations in behaving animals. However, existing small molecule agonists show insufficient potency or selectivity. There is also need for chemogenetic systems compatible with both research and human therapeutic applications. We developed a new ion channel-based platform for cell activation and silencing that is controlled by low doses of the anti-smoking drug varenicline. We then synthesized novel sub-nanomolar potency agonists, called uPSEMs, with high selectivity for the chemogenetic receptors. uPSEMs and their receptors were characterized in brains of mice and a rhesus monkey by in vivo electrophysiology, calcium imaging, positron emission tomography, behavioral efficacy testing, and receptor counterscreening. This platform of receptors and selective ultrapotent agonists enables potential research and clinical applications of chemogenetics.

 
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